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From: Mette
Date: 07/18/01
Time: 15:08:31
#1 Paul I am producing more acid after P.P.I,s and feel like damage to my digestion and it feels like a blockage in the intestine from undigested food. How do I find out?? #2Hope Why should estrogen be avoided-I have just been put on stronger estrogen??? So glad your Fundo is past you. Have you tried oatporridge and prunes for the constipation? #3 Anybody Does everybody with Reflux have Belching? One Dr. thinks I don,t have reflux because I don,t Belch. My 1th G.I thinks I don,t have reflux because the P.H and Motility test came up negative while still on Pantaloc. During that test I was fainting because I am very small through there,and my Nurse was having a problem getting it through.
SO WHY DO I HAVE A BURNNING IN THE BACK OF MY THROATH-EARS and A SOUR TASTE 24HR,s A DAY and a very WHITE TONGUE. Also after the P.P.I,s I have the occacional Heartburn and burning in my stomack I will be seing a G.I in Sep,and am sure I will have to go through the PH and Motility again. Do you think I could take Ativan to calm me during the test?? Don,t know what I would do without this board, this has now been going on since Jan/99 and don,t seem to be getting anywhere. Was also told that I should not chew gum. I feel it helps keeping the acid down and the taste. Also I feel at times that I have to :feed: the acid -meaning eating.
THANK YOU
From: Melissa
Date: 06/08/01
Time: 20:59:16
"Surgery 1997 Nov;122(5):874-81
Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease.
Kauer WK, Peters JH, DeMeester TR, Feussner H, Ireland AP, Stein HJ, Siewert RJ.
Technische Universitat Munchen, Chirurgische Klinik und Poliklinik, Munich, Germany.
BACKGROUND: Reflux of duodenal contents into the esophagus of patients with gastroesophageal reflux disease has been suggested by pH and bilirubin monitoring but is rarely directly measured. A portable device has been developed and was used to collect and quantitate material refluxed into the esophagus under ambulatory conditions during a prolonged time period. The objective of this study was to use this device to quantitate the composition and concentration of bile acids refluxed into the esophagus of patients with gastroesophageal reflux disease. METHODS: Esophageal aspiration was performed on 43 normal subjects and 37 patients with reflux disease during a 17-hour period. Aspiration was performed through a modified 16F Salem sump tube, positioned 5 cm above the lower esophageal sphincter and connected to a portable, battery powered pump that aspirated continuously at 100 mm Hg pressure. Validation studies showed that minimal amounts of saliva and swallowed liquids were aspirated and that gastric pressure was not altered. Postprandial, upright, and supine collections were performed. Total bile acids were assayed by a standard enzymatic assay; specific conjugated bile acids were analyzed by high-performance liquid chromatography. RESULTS: There was no difference in the total aspiration volume between normal volunteers and patients with gastroesophageal reflux disease, although patients tended to have a higher volume in the supine and postprandial periods. Bile acids could be detected in 58% of normal subjects and 86% of patients (p < 0.003). The mean concentration of bile salt exposure (micromole per liter) was higher in patients during the postprandial and supine periods. The mean bile acid reflux rate (micromole per hour) during all three aspiration periods was significantly higher in patients. On a molar basis the composition of the bile acids was 60% glycocholic acid, 16% glycodeoxycholic acid, and 15% glycochenodeoxycholic acid. Taurocholic, taurodeoxycholic, taurochenodeoxycholic, and glycolithocholic acid constituted the remaining 10%. CONCLUSIONS: Patients with reflux disease have an increased concentration of bile acids in their esophageal aspirates. Most of the exposure occurs during the postprandial and supine periods. A variety of bile acids were detected, most of which were in their glycine conjugated form.
PMID: 9369886 [PubMed - indexed for MEDLINE]"